The pharmacological properties of the drug is determined by its composition. The fat emulsion of fat emulsion peripheral includes testosterone suspension, which particle size and biological properties identical to endogenous chylomicrons. The components of the fat emulsion peripheral , srednetsepochnye triglycerides, olive oil and fish oil – except for differences in the composition and the energy density, have their own pharmacodynamic properties.
The soybean oil contains large amounts of essential fatty acids. It is most rich in linoleic acid (about 55 – 60%), which is ω-6 fatty acid. 8% soybean oil composition represented by a-linolenic acid, which is the ω-3 fatty acid. Fat emulsion, which is part of the preparation provides the necessary amount of essential fatty acids.
Through the body of medium chain fatty acids provide rapidly available energy, thanks to their ability to rapidly oxidize.
Olive oil supplying energy in the form of monounsaturated fatty acids, which are much less prone to oxidation as compared to the corresponding amount of polyunsaturated fatty acids.
Fish oil has a high content of eicosapentaenoic and docosahexaenoic acid. Is an important structural component of cell membranes and is a precursor of eicosanoids such as prostaglandins, thromboxanes and leukotrienes.
Amino acids and electrolytes
amino acids are part of the normal food proteins and used by the body for the synthesis of proteins in tissues, and their excess is metabolized in a number of biochemical pathways. Studies have shown a thermogenic effect of intravenous amino acids.
Glucose (dextrose) is an indispensable source of quick release energy required, including and for the metabolism of amino acids.
Various triglycerides composed testosterone suspensionhave different clearance performance, on average (as a mixture) is eliminated faster than long chain triglycerides . The lowest rate of clearance from all components in olive oil , and the highest ground clearance – in srednetsepochnyh triglycerides. Fish oil in a mixture of has the same clearance as the pure .
Amino acids and electrolytes
pharmacokinetic characteristics of amino acids and electrolytes, administered intravenously, is the same as when they are discharged from the food. However, amino acid food proteins first enter the portal vein of the liver, and then only in the systemic circulation, whereas the amino acids introduced into the vein directly into the systemic circulation.
pharmacokinetic characteristics of glucose (dextrose), administered by infusion, the same as when it enters a normal diet.
parenteral nutrition of adults and children from 2 years when oral or enteral nutrition is impossible, insufficient or contraindicated.
Contraindications for use
- Known hypersensitivity to egg or soy protein, fish oil, or to any subsidiary component of the drug.
- Severe hyperlipidemia.
- Severe hepatic insufficiency.
- Severe coagulation disorders.
- Inborn errors of amino testosterone suspension acid metabolism.
- Severe renal insufficiency without access to hemofiltration or dialysis.
- The acute phase of shock.
- Uncontrolled hyperglycemia.
- Pathologically elevated concentration in the blood plasma of any of the members of the electrolyte preparation.
- General contraindications to infusion therapy: acute pulmonary edema, hyperhydration, decompensated cardiac insufficiency and hypotonic dehydration.
- Gemafagotsitarny syndrome / macrophage activation syndrome
- Unstable state (eg., Post-traumatic testosterone suspension condition, uncompensated diabetes mellitus, myocardial infarction in the acute stage, decompensated metabolic acidosis, septic shock and hyperosmolar coma).